Motile eukaryotic cilia and flagella are hair-like organelles responsible for cell motility and mucociliary clearance. Using cryo-electron tomography, it has been shown that the doublet microtubule, the cytoskeleton core of the cilia and flagella, has microtubule inner protein structures binding periodically inside its lumen. More recently, single-particle cryo-electron microscopy analyses of isolated doublet microtubules have shown that microtubule inner proteins form a meshwork inside the doublet microtubule. High-resolution structures revealed new types of interactions between the microtubule inner proteins and the (...) tubulin lattice. In addition, they offered insights into the potential roles of microtubule inner proteins in the stabilization and assembly of the doublet microtubule. Herein, we review our new insights into microtubule inner proteins from the doublet microtubule together with the current body of literature on microtubule inner proteins. High-resolution cryo-electron microscopy structure of the doublet microtubule from Tetrahymena reveals insights into the interactions between microtubule inner proteins with the doublet microtubule tubulin lattice and implication of their functions in the stability and assembly of the doublet microtubule. (shrink)

In this paper we try to initiate a search for an explicite and direct denition of ultraproducts in categories which would share some of the attractive properties of products, coproducts, limits, and related category theoretic notions. Consider products as a motivating example.

In Andreka-Nemeti [1] the class ST r of all small trees over C is dened for an arbitrary category C. Throughout the present paper C de- notes an arbitrary category. In Def. 4 of [1] on p. 367 the injectivity relation j= ) is dened. Intuitively the members of ST r represent the formulas and j= represents the validity relation be- tween objects of C considered as models and small trees of C considered as formulas. If ' 2 ST r (...) and a 2 Ob C then the statement a j= ' is associated to the model theoretic statement \the formula ' is valid in the model a". It is proved there that the Los lemma is true in every category C if we use the above quoted concepts. To this the notion of an ultra- product Pi2Iai=U of objects 2 IOb C of C if we use the above quoted concepts. To this the notion of an ultraproduct Pi2Iai=U of objects 2 IOb C of C is dened in [1], in [2] and in [7] Def. 12. Then the problem was asked there \for which categories is the characterization theorem of axiomatizable hulls of classes of models Mod T h K = Uf U p K true?", where the operators Uf and U p on classes of models is dened on p. 319 of the book [3]. Of course, here in the denition of Uf and U p on classes K Ob C of objects of C we have to replace the standard notion of ultraproducts of models by the above quoted category theoretic ultraproduct Pi2Iai=U of objects of C. That is for any C and K Ob C we dene U p K exactly as in [2] p. 136, but a more detailed denition is found in [7] Def. 17. (shrink)

Food retailers are powerful actors of the agro-industrial food system. They exert strong lock-in effects that hinder transitions towards more sustainable agri-food systems. Indeed, their marketing practices generally result in excluding the most sustainable food products, such as local, low-input, small-scale farmers’ products. Recently in Belgium, several initiatives have been created to enable the introduction of local products on supermarket shelves. In this article, we study three of those initiatives to analyse if the development of local sourcing in supermarkets opens (...) up an opportunity for a transition towards more sustainable agri-food systems. We conceptualise transitions as a shift in governance and ethical values and adopt a pragmatist approach of ethics combined with the systemic perspective of transition studies, to evaluate the impact of these initiatives. Our analysis shows that they mainly contribute to the reproduction of the incumbent agri-food system. It also highlights that first, to be a driver for sustainability transitions, food ethics need to be systemic i.e. relate to a systemic understanding of problems and perspective of sustainability, including social justice. And second, it highlights that governance arrangements involving not only representative organisations of the various agri-food and non-agricultural actors, but also actors upholding ethical values that are currently missing in conventional supply chains and representing excluded and marginalised interests, favour the uptake of such systemic ethics by incumbent actors. Hence, systemic ethics and inclusive governance are key features for initiatives to contribute to a sustainability transition. (shrink)

International integration is deepening, so people develop in all aspects. In society, communities with individuals have relationships in humans' material and spiritual life. When society grows, more people's knowledge of the world needs to learn so that people can understand themselves and act for the development of society. The article studies the thought of Thomas Aquinas to clarify human nature in social life. The paper uses analytical, synthesis, and argumentative methods to explain human nature with its behaviors and perceptions in (...) social life; Aquinas argued that it is human nature to do the right thing to achieve happiness. However, society is more progressive and liberals, but people always realize their lives have many injustices and difficulties. People want their lives to be happy and good but feel depressed. In this article, in an excellent society, people live according to the law and adjust their behavior according to the regulations of society; each person in the society is also better, from which the society is also humane and reasonable that the basis for building a better society in Vietnam. (shrink)

With a focus on the Common Law jurisdiction of England and Wales and the Civil Law jurisdiction of Vietnam, this article provides an analytical framework to address the uncertain jurisprudence of minor offence processes. The article’s approach is to seek an account of crime and criminal process that is most suitable for practice and most compatible with the broad notion of ‘criminal charge’ under international human rights instruments. It is argued that minor offences should be considered forms of less serious (...) crimes that are subject to short periods of imprisonment or non-custodial punishments and dealt with by summary procedures. The fragmentation of minor offences demands an approach to procedural pragmatism and procedural proportionality; that is, the procedure for each type of offence should be proportionate to the severity of punishment and fair as a whole. (shrink)

Analizamos las ideologías para demostrar que su raíz materialista está en el origen de muchos problemas en la sociedad. La economía –es decir, la producción y el consumo– define a la persona humana. El ser humano es un subproducto de la economía. Esta definición ofusca la conciencia que es la base de la ética y por lo tanto de la dignidad de la persona, porque la ciencia y la tecnología se dan siempre en relación con hombres libres cuyos encuentros tienen (...) un significado cultural-ético. No podemos ser indiferentes a lo transcendente que no se puede verificar por experimentos o deducir de manera racional. La fe nos abre un horizonte distinto. (shrink)

This study identifies the relationship between local stakeholder pressures and Korean foreign subsidiaries’ corporate social responsibility. Analyzing the survey data of 177 Korean foreign subsidiaries yielded two important findings. First, local primary stakeholders have a positive impact on responsive CSR activities, but have no influence on strategic CSR activities. Second, local secondary stakeholders in host countries have a strong influence on both responsive and strategic CSR activities. Secondary stakeholders have more influence on strategic than on responsive CSR activities. This article (...) suggests a change in managerial philosophy toward primary and secondary stakeholders, which may have important implications for multinational enterprises in achieving greater success with the design of their CSR activities. (shrink)

Cet ouvrage, destiné aux étudiants, enseignants et chercheurs, s’adresse aussi bien aux philosophes qu’aux historiens de l’art et, plus généralement, à tous ceux qui s’intéressent aux phénomènes artistiques. Il propose une approche novatrice et résolument interdisciplinaire des dispositifs artistiques dans leur dimension historique et discursive comme des œuvres d’art dans leur dimension symbolique. À la faveur d’études iconographiques précises, notamment d’œuvres relevant de l’art roman, les propositions théoriques faites initialement trouvent leur application concrète et montrent leur fécondité. De nombreuses illustrations (...) en noir et blanc dans le corps du texte et un cahier central en couleurs permettent de visualiser les oeuvres étudiées. Un glossaire à la fin du texte fourni une définition précise des concepts utilisés. (shrink)

The traditional soft set is a mapping from a parameter set to family of all crisp subsets of a universe. Molodtsov introduced the soft set as a generalized tool for modelling complex systems involving uncertain or not clearly defined objects. In this paper, the notion of neutrosophic soft set is reanalysed. The novel theory is a combination of neutrosophic set theory and soft set theory. The complement, “and”, “or”, intersection and union operations are defined on the neutrosophic soft sets. The (...) neutrosophic soft relations accompanied with their compositions are also defined. The basic properties of the neutrosophic soft sets, neutrosophic soft relations and neutrosophic soft compositions are also discussed. (shrink)

Resumo: A revolução tecnológica 4.0 e a cooperação internacional têm feito várias mudanças na sociedade. As pessoas passam a desejar uma vida feliza e pacífica ao perceberem que a felicidade é um alvo ou uma meta necessária na vida. O artigo usa o método dialético materialista do pensamento filosófico de Aristóteles de maneira compreensiva, especificando princípios históricos acerca de seu conceito de felicidade comparado ao que temos hoje para mostrar que o valor da felicidade é o valor da beleza. Além (...) disso, o artigo também usa métodos analíticos e sintéticos para esclarecer a visão de Aristóteles de que a felicidade estaria relacionada à coisas materiais, crenças e valores nobres os quais as pessoas esperam conquistar. Este artigo descreve a visão do povo do Vietnã de que a Felicidade é a solidariedade e o apoio mútuo para que vivam juntos em paz, tranquilidade e abundância material. A Felicidade nas vidas dos vietnamitas é necessária para garantir que a vida pessoal de cada um e a vida social sejam civilizadas e modernas e que as pessoas tenham energia pacífica, total e livre. A Felicidade dos Vietnamitas almeja a importância da verdade, da bondade e da beleza. (shrink)

BackgroundThe landscape of clinical research has evolved over the past decade. With technological advances, the practice of using electronic informed consent (eIC) has emerged. However, a number of challenges hinder the successful and widespread deployment of eIC in clinical research. Therefore, we aimed to investigate the views of various stakeholders on the potential advantages and challenges of eIC.MethodsSemi-structured interviews were conducted with 39 participants from 5 stakeholder groups from across 11 European countries. The stakeholder groups included physicians, patient organization representatives, (...) regulator representatives, ethics committee members, and pharmaceutical industry representatives, and all were involved in clinical research. Interviews were analyzed using the framework method.ResultsInterviewees identified that a powerful feature of eIC is its personalized approach as it may increase participant empowerment. However, they identified several ethical and practical challenges, such as ensuring research participants are not overloaded with information and offering the same options to research participants who would prefer a paper-based informed consent rather than eIC. According to the interviewees, eIC has the potential to establish efficient long-term interactions between the research participants and the research team in order to keep the participants informed during and after the study. Interviewees emphasized that a personal interaction with the research team is of utmost importance and this cannot be replaced by an electronic platform. In addition, interviewees across the stakeholder groups supported the idea of having a harmonized eIC approach across the European Member States.ConclusionsInterviewees reported a range of design and implementation challenges which needs to be overcome to foster innovation in informing research participants and obtaining their consent electronically. It was considered important that the implementation of eIC runs alongside the face-to-face contact between research participants and the research team. Moreover, interviewees expect that eIC could offer the opportunity to enable a personalized approach and to strengthen continuous communication over time. If successfully implemented, eIC may facilitate the engagement of research participants in clinical research. (shrink)

Educational philosophy helps to orient the educational development process of each country and develop the capacity of each individual in society. In the educational history of each country, there is always a process of preserving and transferring social heritages. The educational system prepares the next generation to enter society and imparts ideas, values, and beliefs that will shape young people’s thinking and behavior for the rest of their lives. Therefore, this article wishes to clearly and vividly clarify the importance of (...) studying Pragmatism’s educational philosophy to realize its present influence. At the same time, it is crucial to deeply understand the educational process of Pragmatism to derive meaning and clarify the primary function of educating Vietnamese people in the context of current global integration. The article uses the materialist dialectic method with broad and specific historical principles to evaluate Vietnamese education with opportunities and challenges in the current integration process by studying Pragmatism’s philosophical education. The article found that the theory of education by Pragmatism clarifies the role of social educational institutions – schools in the educational process. In parallel, it is a teacher with educational methods and programs that are the basis for educating learners to become comprehensive citizens in the future. And students are the goal and the product that the educational philosophy needs to implement. Research results, the article clarifies the need to develop an educational philosophy for Vietnamese people to build comprehensively in the socialist orientation in the current globalization context. (shrink)

Las experiencias de justicia transicional en la antigüedad griega muestran hasta qué punto las emociones pueden jugar un papel específico en el restablecimiento social de la memoria, la justicia y la verdad. A partir de un estudio de fuentes clásicas provenientes de Atenas, Dicea y Nacone, el propósito del presente trabajo es identificar la ficción afectiva sobre la que reposan estos marcos institucionales: al proyectar el plano emocional desde los individuos hasta la colectividad, se produce una instalación política del páthos (...) que, mediante la planificación, procura superar los efectos traumáticos de la guerra civil y diseñar una comunidad emocional basada en las virtudes de la reconciliación. (shrink)

Animal welfare is an importantsocietal issue in Switzerland. Policy makershave responded with a strict legislation onanimal protection and with two programs topromote animal friendly husbandry. Alsoprivate actors in the meat industry initiatedprograms for animal friendly meat productionto meet consumers' expectations. Labeled meathas a market share of over 20%. Depending onthe stakeholders responsible for the labels,their objectives vary. While retailers want toattract consumers with meat produced in ananimal friendly and environmentally compatiblemanner and with products of consistently goodsensory quality, producers want to (...) keep marketshares and increase their revenues. (shrink)

The study of cultural evolution has taken on an increasingly interdisciplinary and diverse approach in explicating phenomena of cultural transmission and adoptions. Inspired by this computational movement, this study uses Bayesian networks analysis, combining both the frequentist and the Hamiltonian Markov chain Monte Carlo (MCMC) approach, to investigate the highly representative elements in the cultural evolution of a Vietnamese city’s architecture in the early 20th century. With a focus on the façade design of 68 old houses in Hanoi’s Old Quarter (...) (based on 78 data lines extracted from 248 photos), the study argues that it is plausible to look at the aesthetics, architecture, and designs of the house façade to find traces of cultural evolution in Vietnam, which went through more than six decades of French colonization and centuries of sociocultural influence from China. The in-depth technical analysis, though refuting the presumed model on the probabilistic dependency among the variables, yields several results, the most notable of which is the strong influence of Buddhism over the decorations of the house façade. Particularly, in the top 5 networks with the best Bayesian Information Criterion (BIC) scores and p<0.05, the variable for decorations (DC) always has a direct probabilistic dependency on the variable B for Buddhism. The paper then checks the robustness of these models using Hamiltonian MCMC method and find the posterior distributions of the models’ coefficients all satisfy the technical requirement. Finally, this study suggests integrating Bayesian statistics in the social sciences in general and for the study of cultural evolution and architectural transformation in particular. (shrink)

ABSTRACT Amartya Sen’s capability approach is often used in disability research as a normative framework for describing and evaluating the well-being of people with disabilities. Nevertheless, recently, the possibility of going beyond description to the use of the capability approach as an explanatory tool has been raised. However, to allow the use of the capability approach in this way requires grounding it in an appropriate research paradigm. In this paper, critical realism is adopted for this purpose. It is argued that (...) critical realism can provide the ontology needed to justify finding explanations for the way that people with disabilities achieve their valued capabilities. The assumption here is that there are real, emergent structures and mechanisms that underlie empirical capabilities; and that these structures and mechanisms are related to people’s agency, as described by critical realism’s conception of the relationship between structure and agency. (shrink)

Biography of Tran Duc Thao, 1917-1993, a Vietnamese philosopher.

English proficiency is increasingly crucial in Vietnam’s globalized landscape, with standardized tests like IELTS serving as key indicators of language ability. However, effectively translating international test scores to local grading systems remains a challenge. This study aimed to establish a reliable conversion method between IELTS scores and end-of-term grades for high school students in Vung Tau, Vietnam. Utilizing a quantitative, correlational design, we analyzed data from 371 students in grade 10 at Le Quy Don specialized school. Data sources included mock (...) IELTS scores administered by The Forum and official end-of-term grades. Pearson correlation and linear regression analyses were employed to examine the relationship between the variables. A significant positive correlation (r =0.432,p < 0.01) was found between IELTS scores and end-of-term grades. Linear regression analysis yielded a statistically significant model (End-of-term grade = 0.501 × IELTS + 5.843) for predicting grades based on IELTS scores. A conversion table was developed to provide a practical reference for educators. This study provides a valuable tool for bridging the gap between IELTS scores and academic performance in a Vietnamese educational context. The conversion table can inform educational decision-making regarding student placement, targeted support, and curriculum development, ultimately enhancing the understanding of English proficiency expectations for students and educators alike. (shrink)

This study uses a quasi-experimental design to investigate what happens to individual socially responsible attitudes when they are exposed to group dynamics. Findings show that group engagement increases individual attitudes toward social responsibility. We also found that individuals with low attitudes toward social responsibility are more likely to change their opinions when group members show more positive attitudes toward social responsibility. Conversely, individuals with high attitudes do not change much, independent of group characteristics. To better analyze the effect of group (...) dynamics, the study proposes to split social responsibility into relative and absolute components. Findings show that relative social responsibility is correlated with but different from absolute social responsibility although the latter is more susceptible than the former to group dynamics. (shrink)

The present study, using a non-experimental approach, investigated a theoretical concept of best practice, which we recently introduced – namely: a ‘state of consonance’ and a ‘state of disconsonance’ of best practice. Consonance of best practice posits that different levels of best practice, as well as other comparable psychological constructs would cluster or ‘group’ together. Disconsonance of best practice, in contrast, would indicate non-overlapping of contrasting levels of best practice. Taiwanese undergraduates from five private universities in Taipei City and New (...) Taipei City, Taiwan took part in the study by responding to a suite of Likert-scale questionnaires, which took approximately 30–35 min to complete. Cluster analysis, commonly known as ClA, was used to analyze the data and seek theoretical understanding into the nature of the consonance of best practice. Results, overall, showed support for our proposition, resulting in four distinct profiles: ‘a Balanced Profile,’ ‘an Intrinsic Motivation Profile,’ ‘a Current Best Practice + Interest Profile,’ and ‘a Current Best Practice + Motivation Profile.’ This evidence, helping to advance further research development, has a number of practical implications for consideration. For example, how could we use the Balanced Profile to develop learning objectives and/or pedagogical practices that would encourage students to enjoy their learning experiences? (shrink)